DIY: Double-Infused Oil of Oregano |

DIY: Double-Infused Oil of Oregano

Sarena-Rae Santos January 11, 2023

By Sarena-Rae Santos, Natural Health Blogger

Antibiotics are widely used to treat infections and diseases caused by bacteria. While killing harmful bacteria, antibiotics also kill good bacterial strains that we need. Even a single antibiotic dose can lead to detrimental shifts in the composition and diversity of the gut flora (1).

Antibiotics can also lead to long-term changes in the gut flora. After completing an antibiotic dose, most bacteria return after 1–4 weeks, but their numbers usually don’t return to the prior levels (2). Another study discovered that a single dose of antibiotics diminished the diversity of Bacteroides, one of the most dominant bacterial strains, and boosted the number of resistant strains. These consequences remained for up to two years (3)!

As per the CDC, doctors prescribe about 47 million antibiotic courses each year for infections that don’t need antibiotics (4). The unnecessary prescribing of antibiotics has resulted in about 1 in 3 people suffering from yeast-related symptoms or conditions like yeast and candida overgrowth (5).

So what can we do when we need an antibiotic but aren’t comfortable with taking a prescription? 

That’s where oil of oregano comes in. 

Oil of oregano is made by infusing extra virgin olive oil with dried oregano leaves, creating a robust and ingestible “natural antibiotic” widely used in the natural community. 

Health Benefits of Oregano 

Suppose you read When & Why to Choose Oil of Oregano Vs. Oregano Essential Oil, you’d know oregano’s medicinal properties stem from compounds like phenols, terpenes, and terpenoids, with powerful antioxidant properties (6):

  • Carvacrol is the most abundant phenol in oregano and has been shown to stop the growth of several bacteria types (7).
  • Thymol is a natural antifungal that supports the immune system and protects against toxins (8).
  • Rosmarinic acid is a powerful antioxidant that helps protect against free radical damage (9).

Additional benefits of oregano include:

  • Rich in antioxidants (10)
  • Antibacterial properties (11)
  • Antimicrobial properties (12)
  • Antiviral properties (13)
  • Anti-inflammatory properties (14)
  • May prevent and kill certain cancers (15)

Learn more about the benefits of oregano with our oregano herbal profile here.

Double-Infused Oil of Oregano

Double-Infused Oil of Oregano is a lengthier process than most oil of oregano recipes. This recipe is designed to be stronger than the average oil of oregano, allowing for a smaller yet more robust dosage.

Please note: I could not find any herbal profiles from herbalists, but I did find a mainstream source expressing known interactions between oregano and antidiabetic, anticoagulant, and antiplatelet drugs (16).


  • 2 cups dried oregano
  • 1 cup extra virgin olive oil
  • 16 oz. mason jar


Step 1: Add 1 cup of dried oregano into a mason jar, followed by extra virgin olive oil, and close the lid. Save the second cup of dried oregano for the second infusion.

Step 2: Fill a pot with water and bring it to a boil.

Step 3: Place the mason jar in the water, bring it to a boil, and leave for 10 minutes.

Step 4: Remove the jar, shake it, and keep it in a cool, dark cabinet for 2 weeks. Shake the jar at least once a day.

Step 5: Strain the mixture into another mason jar to prepare for the second infusion.

Step 6: Add the second cup of dried oregano and close the lid.

Step 7: Again, fill a pot with water and bring it to a boil.

Step 8: Place the mason jar in the water, boil it, and leave for 10 minutes.

Step 9: Remove the jar, shake it, and keep it in a cool, dark cabinet for 2 weeks. Shake the jar at least once a day.

Step 10: Strain the mixture into another airtight container. It will yield roughly 4 oz. (I used an old 8 oz. Earthley tincture bottle).

Usage & Storage: 10-20 drops (1/8-1/4 tsp) as needed. When stored in a cool, dark place, such as a cabinet, it will last between 6-12 months.

Disclaimer: This post is not intended as medical advice. These statements have not been evaluated by the FDA, and nothing in this post is intended to diagnose, treat, or cure anything. If you have questions, please do your own research or seek advice from a health professional.

What’s your favorite way to use oil of oregano?

This is the writings of:

Sarena-Rae Santos is the founder of The Holistic Hipppie blog, dedicated to natural health and plant-based eating. Her journey to natural health began in 2019 when she swayed away from allopathic medicine after becoming wheelchair-bound due to the side effects of 20+ medications. Complex Regional Pain Syndrome (CRPS) and dizziness due to nystagmus were the sources of her many health complications. Sarena's symptoms diminished after adopting a healthier lifestyle surrounding whole foods and herbs, leaving her a fantastic quality of life and a passion for educating people.


  1. Thank you so much for this recipe! I do have a question: when you say “Place the mason jar in the water, boil it, and leave for 10 minutes”, do you mean let the water continue boiling or turn the heat off and let the jar SIT in the water for 10 minutes?
    Thank you.


    • You’re so very welcome. In my experience, when putting the mason jar in the water, it stops boiling temporarily. So I wait for the water to start boiling again before I start the ten-minute timer.


  2. Thanks for this! My grandma would always give us oil of oregano when we were sick.
    Would you use this on a small child? Say 2 years old? If so, what dosage? If not, I’ve heard under the feet?


  3. Can I use fresh oregano from my plant?


  4. Is it still effective if I didn’t boil it? I did every step but that one.


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Hi, I’m Kate.  I love medical freedom, sharing natural remedies, developing real food recipes, and gentle parenting. My goal is to teach you how to live your life free from Big Pharma, Big Food, and Big Government by learning about herbs, cooking, and sustainable practices.

I’m the author of Natural Remedies for Kids and the owner and lead herbalist at EarthleyI hope you’ll join me on the journey to a free and healthy life!

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