Tablets Of Hydrochlorothiazide Using Natural Disintegrants

In another words a MDT is tablet that dissolves or disintegrate in the oral cavity without the need of water or chewing.

Recently formulation scientist recognized that single component excipients do not always provide the required performance. Co-processing is based on the novel concept of two or more excipients interacting at the sub particle level, the objective of which is to provide a synergy of functionality improvement as well as masking the undesirable cenesthetic hallucination of individual. Co-processing excipients could lead to formation of excipients with superior properties compared with the simple physical mixture component. Co-processed particles of SSG and Crospovidone were prepared using a solvent i. Isopropyl Alcohol, which were used as a direct compressible excipients in mouth dissolving tablet formulation.

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The two super disintegrates were mixed in varied proportion according to 32 factorial design by constant stirring until all the solvent was evaporated. The semi dried mixture of super disintegrates was passed through mesh screen size no.

A two factor three level 32 factorial design is being used to optimize the formulation. Nine such different proportionate mixtures of super disintegrants were prepared accordingly. The concentration of processed Super disintegrants was then optimized for DT 35 secs.

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Keywords: Co-processing, Factorial design, Hydrochlorothiazide, Mouth dissolving tablet. The oral dosage forms are so prolific that their supremacy is not likely to face any serious challenge, at least, in the near future; the oral dosage forms may be intended either for local action on the oral mucosa or for systemic action.

To fulfil these medical needs, the pharmaceutical technologies have developed a novel type of dosage form for oral administration, the mouth dissolving tablets MDTsthat disintegrate and dissolve rapidly in saliva without water. The disintegration time for orally disintegrating tablets generally ranges from several seconds to about l minute. The bioavailability of some drugs may be increased due to absorption of drugs in oral cavity and due to pre-gastric absorption of saliva containing dispersed drugs that pass The basic approach Formulation define: myrmidon Optimization of Hydrochlorothiazide Mouth Dissolving Tablets by Using Co-Processed Superdisintegrants D 2 used in development of MDT is the use of super disintegrants such as crospovidone, croscarmellose, sodium starch glycolate etc.

The bioavailability of some drugs may be increased due to absorption of drugs in oral cavity and due to Tablets Of Hydrochlorothiazide Using Natural Disintegrants absorption of saliva containing dispersed drugs that pass down into the stomach.

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Moreover, the amount of drug that is subject to first pass metabolism is reduced as compared to standard tablets. Excipients with improved functionality can be obtained by developing new chemical excipients, new grade of existing materials and new combination of existing materials. New combinations of existing excipients are an interesting option for improving excipients functionality because all formulations contain multiple excipients. One such approach for improving the functionality of excipients is co processing of two or more excipients.

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Co processing of excipient could lead to formation of excipients with superior properties compared with the simple physical mixture of their components or with individual components. Hydrochlorothiazide was selected for present study.

It is diuretic of benzothiadiazine group and has proved very important and effective drug for management of edema and hypertension. It inhibits sodium reabsorption in the distal tubules causing increased excretion of sodium and water as well as potassium and hydrogen ions. Also it has less solubility in water so to increase its water solubility with the aim of reaching high serum concentration in short period of time is main reason for selection of this drug.

Sodium starch glycolate and sodium stearyl fumarate were gift samples from Maruti Chemicals Pvt. Sodium hydroxide, n-octanol, isopropyl alcohol, methanol and sodium saccharine were purchased from loba chemicals Mumbai, Potassium dihydrogen phosphate was purchased from Qualigens fine chemicals, ethanol was purchased from chamgshu yanguan chemical, China and Hydrochloric acid was purchased from Fisher scientific, Mumbai. All the other Tablets Of Hydrochlorothiazide Using Natural Disintegrants used were of analytical grade. Double distillation water DDW was prepared using in — house distillation unit fabricated at Jencons. Here Preparation and evaluation of physical mixture and co-processed super disintegrants The physical mixture of the SSG and Crospovidone was prepared by simple trituration technique of mixing using glass pestle and mortar.]

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Tablets Of Hydrochlorothiazide Using Natural Disintegrants.

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