Disordered Proteins

Disordered proteins

Distribution of Pico- and Nanosecond Motions in Disordered Proteins from Nuclear Spin Relaxation.

PhD Position in rational drug design of intrinsically disordered proteins Academic supervisor: Prof. Gianni De Fabritiis Aims: Coordination of cellular processes requires time-ordered formation of functional complexes for which the proper timing of binding and unbinding is critical.

Although evidence exists for the relevance of kinetics for biological function, the underlying physical-chemistry mechanisms are still largely unexplored. This is especially true for protein domains without a native folded conformation as, in absence of a structured state, a shift of the equilibrium towards active or inactive states may not be feasible.

Using massively distributed molecular dynamics simulations, high performance codes and new Markov state analytical tools, all largely developed by us, we have shown in a series of pilot studies the capability to resolve molecular kinetics once the multi-millisecond timescale is reached. Preliminary mathematical kinetic models also show that, by modulating the molecular kinetics of competing on-pathway metastable states, it is possible to disordered proteins the disordered proteins of the complex, a novel and potentially important mechanism for intrinsically disordered proteins.

In this project, we aim to investigate the relevance and generality of molecular kinetics for intrinsically disordered protein domains and its modulation by small molecules. We will employ a computationally driven approach to resolve kinetics at atomic resolution, and will integrate our dracula predictions with standard assays and experiments disordered proteins collaborations with experimental experts and local facilities.

References

We expect the candidate to participate in the design and implementation of computational protocols to using the advanced computational developed in the group. Candidate Profile: The candidate will preferably have a profile in biochemistry, chemistry, pharmaceutics, biotechnology, biology. We also have in our group students with a background nightmares during pregnancy computer science, physics, mathematics. Very good communication skills in English are required.

The laboratory is very well equipped with also access to a local GPU cluster and experimental facilities to measure affinities and kinetics. Funding and Eligibility: The project in supported by the Spanish ministry link science.

The application process consist in sending a CV and a proof of your bachelor degree to the formal application page made available. The call is open to EU nationals. disordered proteins

Introduction

Eligible candidates should apply by sending a complete and up to date Disordered proteins together with the names and addresses of two academic referees to: Gianni De Fabritiis gianni. The title of this offer must be clearly stated in any communication. Stanley, S. Esteban and G. De Fabritiis, Kinetic modulation of a disordered protein domain by phosphorylation, Nat.]

Impudence!: Disordered proteins

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Disordered proteins	Jan 01, · Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) have been traditionally considered significantly depleted of aggregation-prone regions. 2 days ago · PhD Position in rational drug design of intrinsically disordered proteins. Academic supervisor: Prof. Gianni De Fabritiis. Aims: Coordination of cellular processes requires time-ordered formation of functional complexes for which the proper timing of binding and unbinding is critical. Although evidence exists for the relevance of kinetics for. 1 day ago · Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration Abstract. A protein’s structure is determined by its amino acid sequence and post-translational modifications, and Introduction. Neurodegenerative diseases including Alzheimer’s (AD).
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