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Feb 13,  · The first pass metabolism refers to the combined action of drug metabolism by the liver and the gut, because certain drugs are digested by microbes in the gut or digestive enzymes. Aug 30,  · Once absorbed by gut transporters, the medications then often have to undergo "first-pass metabolism." When oral medication is administered, it is often processed in large quantities by the liver, gut wall, or digestive enzymes, subsequently lowering the amount of medication that arrives in circulation; therefore, having a lower bioavailability. Apr 09,  · The absorption of the drug depends on first pass metabolism and bioavailability. First pass metabolism refers to “the elimination that occurs when a drug is first absorbed from the intestine and passes through the liver via the portal circulation”. The liver is the primary drug metabolizing organ in the body. Drugs that are easily metabolized have a large first pass . Read more

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