Explain first pass metabolism method pdf sheet
by Mike_B
The first-pass metabolism or the first-pass effect or presystemic metabolism is the phenomenon which occurs whenever the drug is administered orally, enters the liver, and suffers extensive biotransformation to such an extent that the bioavailability is drastically reduced, thus showing subtherapeutic action (Chordiya et al., ). It happens. 3. Explain the purpose of studying pharmacokinetics of drugs 4. Define first-pass effect and explain the sites of first-pass metabolism 5. Classify the different routes of drug administration 6. Explain the advantages and disadvantages of the different routes with few examples of drugs administered by these routes 2. Topic: Drug Absorption. first-pass metabolism. The pH of an injection should also be considered, as extremes of pH can adversely affect the gastric mucosa. Some consideration should also be given to other excipients in the formu-lation such as propylene glycol and ethanol, which may be problematic if large volumes of the injection are required to provide the Modernalternativemama Size: KB. Read more