Explain the first pass metabolism test
by Mike_B
Jul 28, · The first pass effect is a phenomenon in which a drug gets metabolized at a specific location in the body that results in a reduced concentration of the active drug upon reaching its site of action or the systemic circulation. The first pass effect is often associated with the liver, as this is a major site of drug Modernalternativemama: Timothy F. Herman, Cynthia Santos. First-pass elimination takes place when a drug is metabolised between its site of administration and the site of sampling for measurement of drug concentration. Clinically, first-pass metabolism is important when the fraction of the dose administered that escapes metabolism is small and Modernalternativemama: Susan M. Pond, Susan M. Pond, Thomas N. Tozer, Thomas N. Tozer. First-pass metabolism refers to the 'first passage' of drug through the liver, after absorption from the GI tract, as explained above. Read more