What is first pass metabolism definition pharmacology
by Mike_B
Abstract. First-pass elimination takes place when a drug is metabolised between its site of administration and the site of sampling for measurement of drug concentration. Clinically, first-pass metabolism is important when the fraction of the dose administered that escapes metabolism is small and variable. With drugs, the first step in metabolizing occurs through a process known as the first pass effect, in which orally administered drugs are broken down in the liver and intestines. This makes the substance easier to excrete in the urine. Jul 28, · The first pass effect is a phenomenon in which a drug gets metabolized at a specific location in the body that results in a reduced concentration of the active drug upon reaching its site of action or the systemic circulation. The first pass effect is often associated with the liver, as this is a major site of drug Modernalternativemama: Timothy F. Herman, Cynthia Santos. Read more